Abstract
e i 3 i d positive FOBT who have a negative colonoscopy. Among the 99 patients, 70 had a normal colonoscopic xamination and 29 had a potential source of occult bleeding dentified by colonoscopy. Overall, the authors found that 5 of the 99 patients (35%) had an abnormal EGD. Interestngly, the proportion of patients who had an abnormal EGD id not differ between subjects with a normal colonoscopy in diameter (17–27%) is low [6,11,12]. There are several reasons that may explain the low positive predictive value of FOBT for CRC and large polyps, including use of the test in a low-risk screening population, bleeding from trivial colonic lesions other than CRC or large polyps, blood loss from the upper gastrointestinal tract, non-compliance
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