Abstract
A TLC-densitometric method has been established for determination of impurities in chlorpromazine hydrochloride, trifluoperazine dihydrochloride, promazine hydrochloride, and doxepin hydrochloride. Statistical analysis of the data showed the method is precise and highly sensitive. Results from linear regression analysis of the calibration plots were indicative of good linear relationships over wide ranges of concentration. Application of densitometric UV detection at 254 nm and at the wavelengths of maximum absorbance of the substances resulted in increased detectability of zones in the chromatograms compared with visual inspection under a UV lamp. The conditions described enable objective quantitative evaluation of the limiting concentrations of impurities.
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