Abstract
The chemical stability of nicotinic acid (NA) and its esters, namely: methyl nicotinate (MN), ethyl nicotinate (EN), isopropyl nicotinate (IPN), butyl nicotinate (BN), hexyl nicotinate (HN), and benzyl nicotinate (BNN) heated for 1 to 7 h at 120°C on silica gel was determined. The investigations were made using a normal phase-thin layer chromatography (NP-TLC) method and a Camag densitometer. Heating of nicotinic acid and its esters on silica gel 60 at 120°C for 1 to 7 h caused the formation of the substances as a product of their chemical changes. The most stable was nicotinic acid from all the compounds analyzed during the 1 to 7 h of heating. The most stable substances were isopropyl nicotinate and hexyl nicotinate from all the examined esters. The most unstable were ethyl nicotinate, and methyl nicotinate.
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