Use of Theobon-dithiomycocide and compositions created on its basis in treatment of fungal diseases

Abstract

Objective — creation and study of compositions based on Theobon-dithiomycocide with a high keratolytic effect and increased penetration into lesions in the treatment of complicated fungal diseases of the skin and nails.Materials and methods. Theobon-dithiomycocide, urea, and calcium thioglycolate (CaT) were used, when creating the compositions with enhanced penetration into the skin and nails; bird wing rods and nails of healthy persons were used as models. Extemporaneously made compositions were used during the treatment. 18 patients (10 men and 8 women) aged 19 to 64 years were under observation, the term of the disease was from 1 to 30 years. The criteria for the effectiveness of the drugs were the clinical condition of the patients and the results of microbiological studies.Results and discussion. The compatibility of Theobon-dithiomycocide with a number of penetration enhancers and their effect on the penetration of the Theobon-dithiomycocide solution to the lesion site were studied. Original compositions (Theobon-dithiomycocide ointment + urea and Theobon-dithiomycocide + CaT solution) with high keratolytic effect and increased penetration into the skin and nails were proposed. Treatment schemes have been developed, and the condition of patients while using the compositions has been highlighted. Their effectiveness, the absence of side effects and good tolerance of treatment have been proven.Conclusions. The experience of local treatment of fungal diseases with the solution, Theobon-dithiomycocide ointment and original compositions based on it was summarized. The ways to increase the penetration of the Theobon-dithiomycocide solution into the nails were investigated. Theobon-dithiomycocide compositions with gentamicin, urea, and calcium thioglycolate have been developed which increase the penetration of Theobon-dithiomycocide solution into the nail by 5—6 times and provide painless removal of the damaged nail. Treatment regimens for fungal diseases complicated by hyperkeratosis were proposed using original compositions based on Theobon-dithiomycocide made ex tempore. The the­­rapeutic efficacy, the absence of side effects and the good tolerance of the developed drugs, the feasibility of their use for topical treatment of complicated dermatoses and onychomycosis were proved.