Use of the Triethanolammonium Salts of Several of Alkylsulfuric Acids as Dermatologic Vehicles

Abstract

The triethanolammonium salts of dodecyl-, tetradecyl-, hexadecyl-, and octadecyl-sulfuric acids were prepared. Ointment bases were formulated from varying proportions of the salts, the corresponding alcohols, and propylene glycol. The release of salicylic acid, resorcinol, sulfadiazine, iodochlorhydroxyquin, and sulfur from these bases, polyethylene glycol ointment, and white petrolatum was studied by use of tissue digest procedures and microscopic examination, using guinea pigs as the test animals. The triethanolammonium salts of dodecyl-, tetradecyl-, hexadecyl-, and octadecyl-sulfuric acids were prepared. Ointment bases were formulated from varying proportions of the salts, the corresponding alcohols, and propylene glycol. The release of salicylic acid, resorcinol, sulfadiazine, iodochlorhydroxyquin, and sulfur from these bases, polyethylene glycol ointment, and white petrolatum was studied by use of tissue digest procedures and microscopic examination, using guinea pigs as the test animals.