Abstract
We have found that the thiophenesulfonyl group is compatible with the catalytic, asymmetric synthesis of β-lactams from acid chlorides and sulfonyl imines in the presence of a silylated cinchona alkaloid and tris(hexamethyl disilazide) lanthanide complex co-catalysts. The thiophenesulfonyl group can be subsequently removed in moderate yields without causing decomposition of the β-lactam or lowering its stereochemical purity.
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