Abstract
In order to use FT-IR spectroscopy as a technique for immunoassay analysis, the introduction of metallocarbonyl markers in steroids has been studied. By the use of the palladium-catalyzed cross-coupling reaction of steroidal triflates with [trimethyltin ethynyl η 5-cyclopentadienyl manganesetricarbonyl it has been possible to label some steroids with the manganesetricarbonyl moiety. In the case of testosterone, by means of a properly designed synthetic route, it has been possible to introduce the organometallic marker minimizing the impact on the original structure and on the functional groups of the natural hormone thus making this labelled species particularly suitable for CMIA ( C arbonyl M etallo I mmuno A ssay) purposes.
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