Abstract
The preparation and use of the rabbit transverse stomachstrip as an isolated assay tissue for prostaglandins is described. The tissue is relaxed by low concentrations of PGE 2, PGA 2 and PGD 2 and contracted by prostacyclin (PGI 2) and PGF 2α. The decomposition product of prostacyclin, 6-oxo-PGF 1α, has little effect, whereas the endoperoxde PGH 2 and thromboxane A 2 cause a small contraction. Arachidonic acid also contracts the tissue and this response is abolished by indomethacin. This tissue also responds to low concentrations of histamine, acetylcholine, noradrenaline and bradykinin. In conjunction with other bioassay tissues such as the rat stomach strip and rabbit coeliac artery, the rabbit transverse stomach strip provides a convenient method of detection or identification of known arachidonic acid metabolites.
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