Use of the pulse transit time trend to relate tidal breathing and central respiratory events

Abstract

Central sleep apnoea (CSA) is a respiratory event where cessation of breathing effort and airflow occurs. Numerous lumped models have related the physical phenomena in the arterial tree to properties of the arterial wall. However, a limited model is available that describes pulse transit time (PTT) oscillations during CSA and tidal breathing. Data from 28 children (22 males; aged 6.2 +/- 3.6 years) were obtained during overnight polysomnography. Using a lumped-element model, PTT fluctuations during both respiratory events were described and compared with actual experimental data. 222 valid CSA and 222 tidal breathing events were acquired and analysed. For the tidal breathing, undamped PTT oscillations of 3.89 s were predicted while actual data showed a mean value of 3.68 +/- 0.83 s. Conversely, a damped PTT trend was observed during CSA as predicted by the model. The results attained showed that clustered CSA occurrences led to an increase of 7.23 +/- 3.34 per cent in PTT baseline value while the model predicted 7.86 +/- 2.63 per cent. The marginal increase in PTT baseline was expected since the blood pressure and heart rate decreased during such occurrences. The findings herein suggest that the described model has the potential to describe respiratory event characteristics of a sleeping child.