Abstract
The Hosomi-Sakurai allylation is the Lewis acid-promoted carbonyl allylation with nucleophilic allylsilanes. Since its discovery in 1976, this highly useful transformation has found broad applications in the total synthesis of complex natural products, including biologically active polyketides. This review covers only selected examples of natural product total syntheses, over the past two decades, that employ the Hosomi-Sakural allylation or its related reactions as one of the pivotal transformations.
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