Use of Testosterone Propionate and Estrogenic Substance in Treatment of Essential Hypertension, Angina Pectoris and Peripheral Vascular Disease

Abstract

The effect of the sex hormones in cardiovascular disease has been the subject of relatively few clinical investigations. In recent medical literature, however, several reports have been published indicating that these substances may find a useful place in the management of certain vascular disorders. In 1939, Edwards, Hamilton and Duntley (1) observed objective and subjective improvement in 7 male patients with organic peripheral vascular disease following treatment with testosterone propionate. All patients presented evidence of major arterial involvement with loss of the popliteal, femoral, and in one case, the iliac pulsations. In 1940, I presented data (2), indicating that the sex hormones gave promise of being effective in the treatment of vascular insufficiency of the coronary, cerebral, and peripheral circulatory systems. Such salutary results were manifested among patients with angina pectoris in an increase of emotional and exercise tolerance, a decrease in the severity of pain, and a general inc...