Use of symbolic and numeric computation techniques in analysis of biochemical reaction networks

Abstract

AbstractMathematical models of biochemical reaction networks involve nonlinear differential equations with a number of parameters whose values are generally not known a priori. Analysis of such networks includes both analytical and numerical work. The analytical part of such analysis often requires manipulation with massive algebraic expressions that may become challenging due to the inherent nonlinearities and unknown parameters in the model. Computer algebra systems (CASs), which are also capable of performing calculations with symbols and to generate ready‐to‐use computer codes for numerical computations, are excellent tools in such analysis. The present work gives a brief description of how we can benefit from computer algebra to overcome such difficulties and combine symbolic and numeric computation techniques in such analysis with several illustrative biochemical reaction networks. © 2005 Wiley Periodicals, Inc. Int J Quantum Chem, 2006