Abstract
Objective: To study a complex treatment including stem cell preparations with separated Fetal Stem Cells (FSCs) in suspensions and therapy effect on dynamics of arterial blood pressure in the patients with essential arterial hypertension. Material and methods: Comparative study on 25 patients of the main group suffering from essential arterial hypertension was performed to investigate the effect of complex treatment with inclusion of preparations of FSCs in the suspensions containing extracted stem cells of fetal liver, brain and heart along with conventional therapy on a dynamics of ABP ranges in the patients. Control Group included 25 patients with essential arterial hypertension who were compared to the patients in the main group based on all characteristics. The patients were studied before FSCs therapy, over 1, 3 and 6 months after treatment by use of separated FSCs. Results: Increased regulation of vascular tone, better contractile function of the heart and enhanced excretory function of kidneys leading to decrease of Circulating Blood Volume (CBV), Cardiac Output (CO) and Total Peripheral Resistance (TPR) of vessels have been established in the patients. In addition, systolic function of LV myocardium was improved by way of increasing contractile cellular elements within myocardium and/or due to enhanced functional reserves of cardiomyocytes in the recipient. Conclusion: FSCs therapy proved to be safe and highly effective in stabilization of systemic Arterial Blood Pressure (ABP) and contributed to better life quality among the patients with arterial hypertension.
Highlights
Cardiovascular diseases are known to hold the first place among the causes of death for the general population and stay among the main problems at the health care establishments in all economically developed countries worldwide [1]
Increased regulation of vascular tone, better contractile function of the heart and enhanced excretory function of kidneys leading to decrease of Circulating Blood Volume (CBV), Cardiac Output (CO) and Total Peripheral Resistance (TPR) of vessels have been established in the patients
Tendency to improve in the parameters under study as decreased Systolic Blood Pressure (SBP) and pulse pressure, Left Ventricle (LV) wall thinning, increased Glomerular Filtration Rate (GFR) and Pulse Wave Velocity (PWV) have been revealed during our observation (Table 2)
Summary
Cardiovascular diseases are known to hold the first place among the causes of death for the general population and stay among the main problems at the health care establishments in all economically developed countries worldwide [1]. In accordance with the data of World Health Organization (WHO) 17.3 millions of people suffering from cardiovascular diseases died in 2012 and their number constituted 30% among all cases of death throughout the world. A similar problem refers to the countries with both low and high income rates to different extent. More than 80% of mortality cases in the countries with high income accrue to cardiovascular diseases; in particular, the mortality rates owing to the diseases above are almost similar both for women and men population.
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