Abstract
Herein we report a convenient and efficient synthesis of 2-Arylbenzoxazole from the Schiff’s bases of 2-Aminophenol, 3, 5-Diarylisoxazole from α, β-unsaturated ketoxime and 1,3,5-Triarylpyrazole from 2-pyrazoline and N-Arylhydrazone by using milder, less toxic and less expensive-NBS-SiO2, KMnO4-Al2O3, PCC-SiO2 and ACC-Al2O3 as solid-supported oxidizing agents at room temperature. Within the framework of Green Chemistry, the use of solid supported reagents has many advantages such as 1) they are easy to remove from reactions by filtration 2) excess reagents can be used to drive the reaction without introducing any difficulties in purification 3) such solid-supported reagents react differently, mostly more selectively, than their unbound counterparts and 4) toxic, noxious and explosive chemicals are handled more safely when contained on solid support.
Highlights
In the recent years heterocyclic compounds are playing important role in the synthetic organic chemistry
Within the framework of Green Chemistry, the use of solid supported reagents has many advantages such as 1) they are easy to remove from reactions by filtration 2) excess reagents can be used to drive the reaction without introducing any difficulties in purification 3) such solid-supported reagents react differently, mostly more selectively, than their unbound counterparts and 4) toxic, noxious and explosive chemicals are handled more safely when contained on solid support
Isoxazoles act as intermediates in the synthesis of natural products and as building blocks for construction of new molecular systems [11]
Summary
In the recent years heterocyclic compounds are playing important role in the synthetic organic chemistry. Among these heterocycles the bicyclic heterocycles-benzoxazoles [1,2,3] and five membered heterocycles pyrazoles [4,5] and isoxazoles [6,7,8] are known to exhibit various bioactive properties. Isoxazoles act as intermediates in the synthesis of natural products and as building blocks for construction of new molecular systems [11]. It exhibits wide range of medicinal properties [12]. On the other hand 1,3,5-triarylpyrazole occupy an important position in agrochemicals and pharmaceutical industries due to its wide range of bioactive properties such as anti-inflammatory, anti-arrythmic etc. [13,14]
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