Abstract
Characterizing relationships between cell structures and functions requires quantitative mesoscale mapping of intact cells showing subcellular rearrangements following stimulation; however, current approaches are limited in this regard. Thus, we investigated the application of soft X-ray tomography to generate three-dimensional reconstructions of whole pancreatic β-cells at different timepoints following glucose-stimulated insulin secretion. Reconstructions following stimulation show distinct insulin vesicle distribution patterns reflective of altered vesicle pool sizes as they mature and travel through the secretory pathway.
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