Abstract
588 Background: The involvement of axially lymph nodes (ALN) might be changed by neoadjuvant chemotherapy (NAC). The purpose of this study is to investigate the usefulness of sequential FDG-PET/CT for prediction of axillary nodal status after NAC. Methods: A total of 78 stage II or III breast cancer patients who received neoadjuvant docetaxel/doxorubicin chemotherapy were enrolled in this prospective study. The patients received 3 cycles of NAC followed by curative surgery, either breast-conserving surgery or mastectomy with level II or III ALN dissection. FDG-PET/CTs were acquired before chemotherapy and after the first cycle of chemotherapy for early metabolic response and nodal prediction. We obtained chest CTs twice, before and after 3 cycles of NAC. Results: The overall response rate to NAC was 82.1%. Pathologic nodal complete responses (pN0) were obtained in 22 patients (28.3%). Patients with pN0 showed significantly lower post-NAC ALN SUV than those who were pN+ (1.22 ± 1.43 in pN0 vs. 2.13 ± 1.99 ...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
