Abstract
Recombinant human granulocyte macrophage colony-stimulating factor (rhGMCSF) is a regulatory glycoprotein which stimulates proliferation, differentiation, and maturation of myeloid hematopoietic precursors [5]. Administration of rhGM-CSF to normal nonhuman primates and patients with acquired immunodeficiency syndrome, myelodysplasia, and aplastic anemia appears capable of elevating peripheral leukocyte and granulocyte counts [1, 6, 7, 14]. We have been exploring the use of rhGM-CSF following marrow transplantation in man. Two uses of rhGM-CSF which are described here are the use of rhGM-CSF immediately following autologous marrow transplantation for lymphoid malignancies and the use of rhGM-CSF for marrow graft failure.KeywordsAplastic AnemiaGraft FailureLymphoid MalignancyPreparative RegimenGranulocyte CountThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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