Abstract
Clonal heterogeneity and evolution of neoplastic plasma cells are common events in multiple myeloma (MM). Myeloma cells can produce M-proteins as intact immunoglobulins (Ig) with or without excess free light chains (FLC), FLC only or, rarely, no detectable M-protein. Ig are characterized by serum immunofixation electrophoresis (IFE) whereas FLC are quantified by turbidimetry (Freelite), two methods that are not always in concordance. Approximately 95% of MM patients have an abnormal FLC ratio but do not always show the abnormal FLC by IFE.
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