Use of Proton Pump Inhibitors-A drug utilization study

Abstract

Background: In 2006 PPI was the third most frequently prescribed drug in Australia. In United States, UK and New Zealand similar trends were observed. Utilization of proton pump inhibitors is increasing continuously. Differential drug utilization of PPIs are observed along with NSAIDs with antibiotics, Utilization of PPI alone is less, and some newer adverse drugs reactions are being reported, so we planned a study to find out the actual burden of PPI in our area. Methods: 50 registered pharmacies were selected. Then data collection was done after consent of patient or relative having PPI containing prescription and photos of prescription were taken, without any personally identifiable information of patient or physician. Results: 1466 prescription containing PPI were obtained during study. (69.85%) prescriptions were containing NSAIDs along with the PPI. while 55% AMA were used by the physician during the study period. PPI is preferred and prescribed as gastroprotective agents alone or along with antimicrobials and NSAIDs, thus they will reduce the gastrointestinal adverse effects, of concomitant drugs. Conclusion: 45.05% burden of PPI is there in study area observed. PPI are mostly used along with NSAIDs and/or AMA, for their ability to produce gastro protective effect. But their contribution towards adverse effect is to be evaluated. Keywords: PPI, Drug utilization, NSAIDS, Antimicrobial agents