Use of procalcitonin and C-reactive protein as predictors and diagnostic tool of acute appendicitis

Abstract

The aim of the study was to evaluate the role of PCT and CRP in patients with acute appendicitis. The study was conducted in Kirkuk city for the period from January, 2018 to April, 2018 on 50 patients with acute appendicitis with age group 15-54 years. Based on the clinical signs of patients, diagnostic tests and sonar rays, the number of patients with acute appendicitis was assigned to the present study. The study also included 40 healthy persons as control group . The study included the collection of 3 ml of venous blood for identification and measurement of PCT by using ELISA technique and CRP test by using Commercial manual kits. The study also included taking of full information from cases like living situation, age . The study indicated that the maximum mean of PCT was observed in patients with acute appendicitis as compared with healthy persons (17.31±0.51 versus 6.22±0.34 ng/ml) with highly significant difference between the two groups. The maximum rate of CRP +ve was observed in patients with acute appendicitis as compared with healthy persons (84%versus 10% ng/ml) with highly significant difference between the two groups. The study found that means of WBCs count and neutrophils count were significantly higher in patients with acute appendicitis as compared with healthy persons. The study showed that there was positive correlation of PCT and CRP with each of WBCs and neutrophil counts and a strong positive correlation of PCT with CRP in patients with acute appendicitis. The highest rate of patients with acute appendicitis (40%) was in the age group 15-24 years followed by the age group 25-34 years while the lowest rate was in the age group 45-54 years. It was concluded that PCT and CRP considered as in important non-invasive diagnostic tool of acute bacterial appendicitis