Use of preintervention intravascular ultrasound in patients with acute myocardial infarction

Abstract

This study was designed to determine whether preintervention intravascular ultrasound (IVUS) imaging can assist in predicting the likelihood of acute coronary occlusion after primary angioplasty. Primary angioplasty is in widespread use for the treatment of acute myocardial infarction (AMI), although its usefulness is sometimes compromised by postprocedural acute coronary occlusion. If preintervention IVUS could be used to predict acute coronary occlusion, the task of determining treatment strategies for AMI would be significantly eased. Preintervention IVUS was performed without complications in 46 patients with AMI using manually prepared contrast medium. Coronary angiography was performed 1 hour after successful percutaneous transluminal coronary angioplasty. Acute coronary occlusion was seen in 13 of 46 patients (28%). There were no differences in the clinical characteristics and angiographic results between the patients with and without occlusion. In patients with acute occlusion, the incidence of eccentric plaque (85% vs 36%, p <0.01) and echolucent area (92% vs 15%, p <0.01) was significantly higher than in the occlusion-free patients. Most of the echolucent areas were associated with eccentric plaques (88%). Eccentric plaques characterized by echolucent areas are prone to acute occlusion after primary balloon angioplasty for AMI. Preintervention IVUS is both a safe and a useful adjunct to primary angioplasty.