Use of platelet-rich plasma in the treatment of medication-related osteonecrosis of the jaw. A case report

Abstract

Introduction : Medication-related osteonecrosis of the jaw (MRONJ) is an area of uncovered bone in the maxillofacial region that does not heal within 8 weeks after identification by a healthcare provider, in a patient who is receiving or has been exposed to bisphosphonate therapy without previous radiation therapy to the craniofacial region. Case Description : The survey was conducted in 2018/2019. It was conducted at the Clinic of Maxillofacial Surgery, St. George University Hospital, Plovdiv, Bulgaria. In order to conduct the study, we obtained informed consent from the patient, who was 63 years of age. We have diagnosed medication-related osteonecrosis of the lower jaw. We performed bone resection and applied platelet-rich plasma (PRF) in order to enhance soft tissue healing. Discussion : Management of MRONJ remains a challenge and controversial topic. Multiple treatment approaches have been introduced to control MRONJ. Surgical treatment remains one of the most reliable methods but it also needs to take advantages of advanced scientific researches and technologies. One of these achievements is the use of a platelet-rich fibrin matrix (PRFM). Conclusion: In addition to the established surgical treatment options, we can add the application of platelet-rich plasma as an adjuvant treatment for MRONJ.