Abstract
In order to circumvent the problem of silanols polymerization in food supplement or cosmetics, the stabilizing power of phenolic molecules such as vanillin and frambinone was evaluated using two different siliceous molecules: orthosilicic acid and monomethylsilanetriol. NMR analyses confirmed the absence of polymeric species in formulations, conferring it a good bioavailability. The Silicon-phenol complexes demonstrated interesting biological properties on skin, collagen and cellular ageing proving that this complex reveals all the power of Silicon.
Highlights
Silicon is one of the most common elements in nature
Complexes of bioavailable silicon molecules In order to overcome this problem, in the present research, we focused on the elaboration of Silicon complexes with well-defined properties such as bioavailability, stability, safety and without the presence of halogenated siliceous molecules as in the case of the traditional use of HMDS (Hexamethyldisiloxane)
It has been shown that the number of free hydroxyl group on the Silicon atom is a major key factor for both the solubility and the biological activity of the chemicals [18]. This is why our research was oriented to two types of siliceous molecules, organosiliceous complexes and orthosilicic acid (OSA) complexes with the aim to obtain the best-balanced combination of bioavailability and stability
Summary
SilInnov Previous DexSil Labs, UCL Education Université Claude Bernard Lyon 1, Belgium. Received date: December 22, 2017; Accepted date: January 04, 2018; Published date: January 08, 2018
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