Use of Parecoxib on postoperative analgesia for the elderly patients undergoing colorectomy

Abstract

Objective To evaluate Parecoxi on postoperative analgesia for the elderly patients undering colorectomy. Methods 82 patients were randomly divided into group of 44 patients undergoing open surgery and 38 patients receiving laparoscopic colorectomy. 22 patients in open surgery using Parecoxib sodium combined with PCA analgesic way were named as observation group, while the other 22 patients using placebo combined with PCA analgesic way named as control group. 19 laparoscopic surgery patients using Parecoxib sodium analgesia were named as observation group, while the other 19 patients using Tramadol analgesia named as control group. Results In the absence of any differences of VAS pain score, in the open surgery group, the average dosage of Fentanyl in observation group was (0.45±0.23)mg vs. (0.78±0.16)mg in observation group (P<0.05). Parecoxib reduced the dosage of Fentanyl of PCA in the open surgery group. In laparoscopic group, at the time of postoperative 6, 12, 24, 48, 72 h, in the observation group patients resting pain scores were 5.01±0.36, 4.44±0.37, 4.02±0.46, 3.35±0.52, 2.54±0.23 respectively, while in the control group patients resting pain scores were 5.86±0.45, 5.03±0.64, 4.89±0.75, 3.94±0.73, 2.56±0.41 respectively, (P<0.01). The postoperative gastrointestinal function recovery time was (3.1±0.7) d in observation group vs.(5.9±0.4) d in the control group (P<0.01). The incidence of postoperative nausea and vomiting, were lower in observation group, (P<0.01). Conclusion Parecoxib can be used for postoperative analgesia in elderly patients with colorectal cancer, reducing the dosage of opioids, and protecting the patient′s immune function. Key words: Colorectal neoplasms; Cyclooxygenase-2 inhibitor; Analgesia; Aged