Abstract
Objective:To ascertain patients and physician views regarding hazard and compliance of oral liquid Vitamin D glass ampoule and tablets.Methods:This cross sectional survey was conducted from November 1st 2016 to 15th December 2016. Patients who were prescribed Vitamin D glass ampoule from oral route in last three months were included along with physicians who routinely prescribe vitamin D after taking informed consent. The participants were asked about injuries related to the use of glass ampoule, ease of using this from, after taste preference of tablet or injectable form as well as demography. Data was analysed with SPSS version 24.0.Results:Total 182 patients were included in the study with mean ± SD age of 39.4 ± 12.4 years. Majority of patients, 80.2% (142) said they prefer oral tablet in preference to injectable ampule in oral form if given choice while prescribing Vitamin D. Moreover 66.7% (64) doctors prefer to prescribe tablet form of Vitamin D instead of injection as oral form for vitamin D deficiency among their patients. One third of patients, 33% (n=59) sustained injury while breaking the ampule which included minor self-controlled bleeding by glass particles in 50% (n=35). Less than half of doctors 46.9% (n=45) said they taught their patients about usage of injectable Vitamin D ampules.Conclusion:Majority of patients prefer Vitamin D tablet instead of Oral liquid in glass ampoule if they got the choice among two. The results of this study provide important implications for our doctors about patients concern of hazard, after taste and compliance with orally administered Vitamin D glass ampoules.
Highlights
Vitamin D deficiency is pandemic and is present in more than one billion people all over the world.[1]
Were you taught by health care professional how to properly break glass ampule? Did you break glass ampule yourself? Did you feel comfortable breaking the glass ampule? Did you injure yourself while breaking glass ampoule? What was the extent of Injury? Laceration Self-controlled bleeding Bleeding that required bandaging Others How often you spill Liquid Vitamin D out while breaking glass ampule? Frequently Often Sometimes Rarely Never Have you ever found a broken glass piece in your medicine while taking it? Is there any bad taste after taking Liquid Vitamin D injection ampule? If given preference which form of medication you will choose? Oral tablet
The study was first of its kind in term of documenting patient’s and doctor experiences about the hazard, compliance, risk of two most common form of Vitamin D; oral glass ampoules and oral tablets
Summary
Vitamin D deficiency is pandemic and is present in more than one billion people all over the world.[1]. Vitamin 25(OH) D levels less than 20 ng/ml are taken as cut off for vitamin D deficiency.[3] Hypovitaminosis D has been associated with various diseases including hypertension, cardiovascular diseases (CVD), type-1 and type-2 diabetes mellitus (DM), obesity, dyslipidemia, congestive heart failure, multiple. Oral Vitamin D glass ampoule and tablet sclerosis, Parkinson disease, rheumatoid arthritis, cognitive impairment, several types of cancers such as prostate, breast and colon cancers, viral and bacterial infections, chronic obstructive pulmonary diseases, autoimmune diseases, dementia and complications of pregnancy.[4,5,6] Pakistani population is very deficient in Vitamin D. It is reported that up to 91.50% of some areas were found to have Vitamin-D deficiency in Karachi.[7]
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