USE OF NANODISPERSIVE DERMATOTROPIC GEL IN THE COMPREHENSIVE TREATMENT OF TROPHIC LESIONS OF THE LOWER LIMBS IN PATIENTS WITH DIABETES MELLITUS

Abstract

Given the rapid increase in the global prevalence of type 2 diabetes mellitus, an increase in the number of chronic diabetic wounds and ulcers is predicted. The problem of treating and predicting the course of trophic lesions of the lower limbs in patients with diabetes mellitus has remained unresolved until now. Successful treatment of trophic wounds in diabetic patients is a serious multidisciplinary challenge. Therefore, the development of new drugs, methods and treatment is crucial. “Cerera” Gel-Balm is an original development based on an antioxidant complex with cerium dioxide ions, providing the product with unique biological properties. The gel accelerates the regeneration processes of damaged tissues, provides antimicrobial, anti-inflammatory and anti-oedematous effects, and is effective in viral soft tissue infections. The purpose of the study was to improve the treatment outcomes of patients with diabetes mellitus and trophic ulcers by using the nanodispersive cerium dioxide-based dermatotropic gel. Methods and participants. The study was carried out at the surgery unit of Poltava Central District Clinical Hospital and the endocrinology unit the 2nd Poltava Municipal Clinical Hospital. Two distinct clinical cases have been presented where the suggested local treatment was included into the comprehensive treatment strategy. Photographic evidence of wound healing and the outcomes of laboratory and instrumental diagnostic methods are provided. Conclusions: The application of the suggested gel, following an extended but ineffective standard comprehensive treatment, has demonstrated a notable reduction in trophic ulcer healing time. It effectively safeguards against wound infections and the onset of new infections while promoting the growth of granulation tissue. This multifaceted positive impact of the gel components on trophic ulcer healing significantly enhances the patients' quality of life.