Use of Multiomics Technology in Genomic Study and Role of DNA Adductomes in Identifying Cause of Certain Diseases and Environmental Pollutions

Abstract

With the advancement of –omic research in biological sciences , new vistas have opened in different disciplines of Genetics and health sciences. Again this revolution in these disciplines is possible with technological improvement of DNA sequencing technology. This modern technology is known as Next Generation Sequencing. Now-a-days biological analysis is done using multiple –omes such as Genome, Proteome, Transcriptome, Epigenome, Metabolome etc. Recently another Biological technique known as DNA Adductome is used to detect the cause of DNA damage done by many chemical agents, drugs, pollutants etc. Details of Next Generation Technology and Alignment technology have been discussed in the article. The application of Next Generation Sequence (NGS) technology has been applied for the improvement of crop plants. Another-omic technology is the study of DNA Adductomes. When DNA is bound to any chemical it is called DNA Adduct. The adduct formation is leading to DNA damage resulting into mutation. The origin of many human diseases like cancer and others have been found to be due to the formation of DNA adducts. The way of adduct formation in DNA has been discussed with special reference to human health. The measurement and identification of environmental pollutants can be monitored through the study of DNA Adduct. Thus this multiomic technology including DNA Adductomes may bring revolution in medicine and toxicological studies.