Abstract
Murine monoclonal antibodies are used to abrogate immunological rejection of vascularised organ grafts in humans. The most widely-used antibody, muromonab CD3 (OKT3), has specificity for the human peripheral T cell antigen CD3. Systemic administration of muromonab CD3 in essential organ transplantation is associated with 2 major types of complications: infections and the so-called cytokine release syndrome. In addition, most recipients produce antibodies to the heterologous murine immunoglobulin. Muromonab CD3 has also been implicated in precipitating some ocular complications. Some of these adverse effects are likely to be attendant on the administration of any immunosuppressive murine monoclonal antibody, irrespective of specificity.
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