Abstract
Background According to the American Psychiatric Association practice guidelines, if a patient with Major Depressive Disorder (MDD) has not responded or achieved only a partial response after 4-8 weeks of therapy, a dose change, switch to a new drug, or augmentation therapy is recommended [1]. Combined use of standard antidepressants with dopaminergic agents and psychostimulants can lead to accelerate and enhance response if administered early in the course of treatment [2].
Highlights
According to the American Psychiatric Association practice guidelines, if a patient with Major Depressive Disorder (MDD) has not responded or achieved only a partial response after 4-8 weeks of therapy, a dose change, switch to a new drug, or augmentation therapy is recommended [1].Combined use of standard antidepressants with dopaminergic agents and psychostimulants can lead to accelerate and enhance response if administered early in the course of treatment [2]
Initial results show that the combination with metilphenidate can be useful for patients in need of a rapid improvement in depression, in those with chronic treatment-resistant depression but the tolerability of the combination may limit its use [2]
Methylphenidate is used in 3% of the sample with an average dose of 20 mg/d
Summary
According to the American Psychiatric Association practice guidelines, if a patient with Major Depressive Disorder (MDD) has not responded or achieved only a partial response after 4-8 weeks of therapy, a dose change, switch to a new drug, or augmentation therapy is recommended [1]. Combined use of standard antidepressants with dopaminergic agents and psychostimulants can lead to accelerate and enhance response if administered early in the course of treatment [2]
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