Abstract
Low toxic and synthetic adjuvants were investigated in the induction of protective immunity against Friend murine retrovirus-induced erythroleukaemia by immunization with inactivated Friend murine leukaemia helper virus (F-MuLV). 6-O-(2- tetradecylhexadecanoyl)-N- acetylmuramyl- l-alanyl- d-isoglutamine (B30-MDP) showed a significant enhancement of the protective immunity against Friend virus-induced erythroleukaemia not only in H-2 a/b mice known to make good immune responses to F-MuLV envelope, but also in H-2 a/a mice which are usually unable to respond to F-MuLV envelope protein. Another analogue of N- acetylmuramyl- d-isoglutamine (MDP), N α- acetylmuramyl- l-alanyl- d-isoglutaminyl -N ε- stearoyl- l-lysine [MDP-Lys(L18)], which has been shown to enhance non-specific protective activity against bacterial and viral infections, however, showed no adjuvant activity in the present system. A combined adjuvant of the synthesized mycobacterial cord factor, trehalose dimycolate (TDM) and detoxified bacterial endotoxin, monophosphoryl lipid A from Salmonella minnesota, gave good protection which was comparable to complete Freund's adjuvant in both H-2 a/b and H-2 a/a mice.
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