Abstract
Neurodegenerative disorders (NDD) have become the common global health burden over the last several decades. According to World Health Organization (WHO), a staggering 30 million people will be affected by Alzheimer’s disease in Europe and the USA by 2050. Effective therapies in this complex field considering the multitude of symptoms associated with NDD indications, have not been found yet. Based on the results of NDD related studies, prevention appears to be the promise alternative. Antioxidative and anti-inflammatory properties are hypothesized for natural phenolics, a group of plant secondary products that may positively impact neurodegenerative diseases. In these studies, phenolic-rich extracts from less common fruit species: Blue honeysuckle (Lonicera edulis, Turcz. ex. Freyn), Saskatoon berry (Amelanchier alnifolia Nutt.), and Chinese hawthorn (Crateagus pinnatifida Bunge) were obtained and analyzed to detect neuroprotective substances content and establish a potential therapeutic value. High performance liquid chromatography with electrochemical detection was optimized and further applied on analysis of the extracts of less common fruit species. It was observed that Chinese hawthorn and Blue honeysuckle extracts are potent source of neuroprotective phenolic antioxidants. In accordance the results, it appears that the fruit or formulated products may have the potential for the prevention of neurodegenerative diseases.
Highlights
Much interest has been generated in drug discovery and development from progress in the global propagation of neurodegenerative disorders (NDD)
Gallic acid (3,4,5-trihydroxybenzoic acid, (GA, Figure 1) is a naturally occurring antioxidant that has shown a multitude of biological activities [62, 63], including neuroprotective ones
Substances without the electrochemical activity are antioxidant activity less, on the other hand, the activity is expected from the sort of substances disposing low levels in half-undulate signal
Summary
Much interest has been generated in drug discovery and development from progress in the global propagation of neurodegenerative disorders (NDD). It has been shown that the antioxidant activity varies with the types of phenolic compounds present in the fruit. High performance liquid chromatographic analysis are most commonly employed to identify antioxidants in beverage samples using UV detection and to quantify them [54,55,56,57]. Gallic acid (3,4,5-trihydroxybenzoic acid, (GA, Figure 1) is a naturally occurring antioxidant that has shown a multitude of biological activities [62, 63], including neuroprotective ones.
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