Abstract
Acne is a multifactorial skin disorder frequently observed during adolescence with different grades of severity. Multiple factors centering on sebum secretion are implicated in acne pathogenesis. Despite the recognized role of sebum, its compositional complexity and limited analytical approaches have hampered investigation of alterations specifically associated with acne. To examine the profiles of lipid distribution in acne sebum, 61 adolescents (29 males and 32 females) were enrolled in this study. Seventeen subjects presented no apparent clinical signs of acne. The 44 affected individuals were clinically classified as mild (13 individuals), moderate (19 individuals), and severe (12 individuals) acne. Sebum was sampled from the forehead with Sebutape(TM) adhesive patches. Profiles of neutral lipids were acquired with rapid-resolution reversed-phase/HPLC-TOF/MS in positive ion mode. Univariate and multivariate statistical analyses led to the identification of lipid species with significantly different levels between healthy and acne sebum. The majority of differentiating lipid species were diacylglycerols (DGs), followed by fatty acyls, sterols, and prenols. Overall, the data indicated an association between the clinical grading of acne and sebaceous lipid fingerprints and highlighted DGs as more abundant in sebum from adolescents affected with acne.
Highlights
Acne is a multifactorial skin disorder frequently observed during adolescence with different grades of severity
Studies aimed at the identification of lipid alterations involved in acne pathogenesis date back to the early 70s to late 80s [9,10,11,12,13,14]; the complexity of the sebum composition has represented a major limitation to understanding lipid modifications involved with acne
Multiple factors involved in acne pathogenesis include increased sebogenesis and occurrence of inflammatory processes
Summary
Acne is a multifactorial skin disorder frequently observed during adolescence with different grades of severity. To examine the profiles of lipid distribution in acne sebum, 61 adolescents (29 males and 32 females) were enrolled in this study. The data indicated an association between the clinical grading of acne and sebaceous lipid fingerprints and highlighted DGs as more abundant in sebum from adolescents affected with acne.—Camera, E., M. No separative spectroscopic methods based on NMR have been used for the quantitative analysis of sebum lipids independent of their fatty acid composition [19]. Acne is a complex and multifactorial skin disorder targeting the pilosebaceous unit, wherein the sebaceous gland produces and secretes a lipid-rich mixture known as sebum.
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