Abstract
ABSTRACTThe linear solvation energy relationship (LSER) model was utilized to delineate which specific intermolecular interactions are responsible for changes in retention for a variety of well‐characterized analytes when different additives were used in reversed‐phase high‐performance liquid chromatography. The effects of additives such as organic [sodium dodecyl sulfate (SDS), cetyltrimethylammonium bromide (CTAB)] and inorganic [sodium dihydrogen phosphate (NaH2PO4), disodium hydrogen phosphate (Na2HPO4)] salts with 30–50% (v/v) acetonitrile (ACN) on the LSER coefficients were studied. The ability of the LSER model to account for the chemical interactions underlying solute retention was demonstrated. LSER as a potential predictive tool can direct us to choose proper mobile phase additive to separate different kinds of compounds. Copyright © 2011 Curtin University of Technology and John Wiley & Sons, Ltd.
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