Abstract
Aim:Uterine transplantation (UTx) is proposed for treatment of uterine factor infertility. Our aim was to assess whether Endoscopic Laser Speckle Contrast Analysis (eLASCA) could evaluate pelvic blood flow at anastomotic sites required for sheep and rabbit UTx.Results/methodology:eLASCA detected blood flow in rabbit UTx #7 and #9. In sheep UTx #2, #3 and #5, the results allowed us to conclude that blood flow was present in the uterine graft following transplantation; and post-UTx, the animal had heart and respiratory rates, and oxygen saturation compatible with a normal hemodynamic status.Conclusion:These preliminary results establish the potential of Laser Speckle Contrast Analysis as noncontact and real-time tool for observation of spatially-resolved blood flow from which other parameters can be derived.
Highlights
This data gives us information related to presence of adequate blood flow to a particular tissue, and from that information, heart and respiratory rates and oxygen saturation are calculated
The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed
It was only attempted preretrieval and post-UTx in UTx #2, #3 and #5, and preretrieval only in UTx #4 because the first autotransplant was abandoned and the fourth ewe demised very early during the surgery
Summary
Uterine transplantation (UTx) is proposed for treatment of uterine factor infertility. The objective of the study was to assess whether Endoscopic Laser Speckle Contrast Analysis could be used to evaluate pelvic blood flow at anastomic sites required for a successful uterine transplantation in two animal models. The use of Laser Speckle Contrast Analysis is the first such case in gynecology and has demonstrated promise of possible future use in humans. This data gives us information related to presence of adequate blood flow to a particular tissue, and from that information, heart and respiratory rates and oxygen saturation are calculated
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