Abstract
Photodynamic therapy is a method for achieving selective tissue destruction of neoplastic and atypical proliferative cells using a chemical photosensitizer, which accumulates within the tumor, and a light source to activate a free radical cascade. This method has been used for a variety of malignant and premalignant conditions. We have been using photodynamic therapy in the larynx for intractable and difficult keratosis with atypia using a nebulized formulation of aminolevulinic acid activated with the 585-nm pulse dye laser (Cynosure, Chelmsford, MA). We can perform this procedure in the office under local anesthesia using a flexible nasopharyngoscope with a 2.5-mm working channel. We have found it to be a valuable adjunct for patients with widespread keratosis and dysplasia. In this article, we describe our methodology and application of this technology.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Operative Techniques in Otolaryngology - Head and Neck Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
