Abstract

➤ A review of the evidence-based research on the efficacy of intra-articular corticosteroid injections of the osteoarthritic knee was inconclusive.➤ Combining intra-articular corticosteroid injection with a higher-dose anesthetic may compound chondrotoxic effects.➤ Compared with corticosteroid injections for osteoarthritis, intra-articular viscosupplements have not shown a substantial difference in pain relief or functional outcomes.➤ Although rare and usually transient, systemic effects of intra-articular corticosteroid injections may occur and can be influenced by the type, frequency, and dosage of the corticosteroid used.➤ Practitioners are encouraged to use corticosteroid injections judiciously to treat pain and joint inflammation from osteoarthritis and inflammatory arthritis of large joints.

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