Abstract
The Indian Council of Medical Research initiated a, multicentric trial with prostaglandins in 1976 to assess the safety and efficacy of their use in midtrimester abortions, PGF 2αand 15-Me-PGF 2α were compared using the intra-amniotic (I.A.) route, 15-Me-PGF 2α was also evaluated by extra-amniotic (E.A.) route. With intra-amniotic instillation, success rate was 88.1 per cent with PGF 2α and 93.0 per cent with 15-Me-PGF 2α within 48 hours and by the extra-amniotic route it was 78.1 per cent within 36 hours. The mean induction-abortion interval was 19 hours with I.A. and 14.8 hours with E.A. Abortions were complete in 48.8 per cent of the women following I.A. PGF 2α, 56.0 per cent following I.A. 15-Me-PGF 2αand only 23.0 per cent following E.A. administration. Vomiting and diarrhoea were the most commonly reported side effects. Cervical injuries were 4.7 per cent with I.A. PGF 2α, 1.4 per cent with I.A. 15-Me-PGF 2α and only 0.6 per cent with E.A. route.
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