Use of in vivo and mechanistic evidence for the development of structural alerts for the prediction of non-genotoxic carcinogenicity

Abstract

Receptor (PR) from the steroid hormone receptors superfamily. AR binding has been associated with i) the transient stimulation of cell proliferation and consequent tumour formation in the prostate of rats and humans [3], and also in organs such as the liver [4] and ii) strong tumour promoter activity to enhance carcinogenicity of endogenous species such as oestrogen reactive metabolites or reactive oxygen species [3]. PR binding has been correlated i) with cell proliferation in normal human epithelial breast cell via an indirect production of paracrine growth factors [5] as well as in rodent and/or human mammary tumour cells with medroxyprogesterone acetate [6] and ii) tumour promoter activity [7]. Use of in vivo and mechanistic evidence for the development of structural alerts for the prediction of non-genotoxic carcinogenicity Laurence Coquin, Laura Gibson, Mukesh L. Patel and Susanne A. Stalford. Lhasa Limited, 22-23 Blenheim Terrace, Woodhouse Lane, Leeds LS2 9HD, UK