Abstract
Introduction: Diabetes mellitus (DM), a metabolic disorder, is known to be highly prevalent in people aged 40 - 60 years in developing countries whereas in developed countries, it mostly affects people above the age of 60 years. It is of two types: DM type I, an autoimmune disorder that mostly onsets after an infection and DM type II that is commonly associated with obesity. Several treatments are available for the treatment of DM, but none has successfully cured diabetes. Nowadays, stem cell therapy is being investigated for use in the treatment of DM and has shown positive results. Case Report: Our study presented results of three diabetic patients who were treated with human embryonic stem cell (hESC) therapy. Following the therapy, blood glucose levels were reduced. An improvement was observed in eye sight, stamina, gait pattern endurance, mental focus ability and muscle strength. There was a reduction in secondary side effects of high blood sugar such as affectation of cardiac, kidneys, polyneuropathy, vision etc. No adverse events and teratoma formation were observed after the treatment. Conclusion: It was concluded that hESCs showed good therapeutic potential in the treatment of patients with diabetes.
Highlights
Diabetes mellitus (DM), a metabolic disorder, is known to be highly prevalent in people aged 40 - 60 years in developing countries whereas in developed countries, it mostly affects people above the age of 60 years
DM type I is caused by a cellular-mediated autoimmune destruction of the β-cells of the pancreas that results in significant drop in the insulin secretion and the insulin deficiency
We presented three cases of DM patients who were treated with human embryonic stem cell (hESC) therapy
Summary
Diabetes mellitus (DM), a metabolic disorder, is known to be highly prevalent in people aged 40 - 60 years in developing countries whereas in developed countries, it mostly affects people above the age of 60 years. It is of two types: DM type I, an autoimmune disorder that mostly onsets after an infection and DM type II that is commonly associated with obesity. Diabetes mellitus (DM) is estimated to affect around 285 million people worldwide and this number is expected to reach 439 million people by 2030 It is highly prevalent in people aged 40 - 60 years in developing countries whereas in developed countries, it mostly affects people aged above 60 years [1]. There is a wide list of complications associated with chronic hyperglycemia such as cardiovascular disease (CVD), coronary artery disease (CAD), myocardial infarction and peripheral arterial disease with the consequence of limb amputation, neuropathy, retinopathy, nephropathy, cardiomyopathy and diabetic foot ulcers [5]-[9]
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