Abstract
Background The source of hospital-acquired chickenpox infection may be presumed from a known exposure, but has not been previously proven using genomic analysis. Objective Investigation of suspected VZV transmission was done using single nucleotide polymorphism genomic analysis. Study design Comparison was made of viral isolates from two patients with chickenpox on the same ward who were not known to have had direct contact. Results An identical genotype in the variable R1 region of the VZV was isolated from the two patients. Conclusion Inapparent hospital-acquired transmission was the most likely route of infection.
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