Use of Food Challenge to Distinguish Food Protein-Induced Enterocolitis Syndrome from Hereditary Fructose Intolerance

Abstract

RATIONALE: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy characterized by vomiting, diarrhea, lethargy, and dehydration occurring within hours of the consumption of a triggering food protein. Hereditary fructose intolerance (HFI) is an autosomal recessive enzyme deficiency resulting in abnormal fructose metabolism which can present acutely as nausea, vomiting, abdominal pain and hypoglycemia following the ingestion of a fructose load but can progress to failure to thrive, liver failure, and renal dysfunction.