Abstract
Hemorrhagic cystitis is a known complication of pelvic irradiation that occurs in up to 9% of patients who have received full dose radiation therapy.1 Hemorrhage from radiation induced cystitis can range from mild hematuria that can be treated with bladder irrigation, intravesical instillation and/or aminocaproic acid to severe bladder hemorrhage that necessitates multiple blood transfusions and requires more invasive therapy such as formalin instillation, vascular embolization or cystectomy and/or urinary diversion. MullerMattheis et al reported the use of fibrin sealant in the treatment of cyclophosphamide induced hemorrhagic cystitis.2 However, to our knowledge there are no reported cases of the use of fibrin sealant in the treatment of radiation induced hemorrhagic cystitis.
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