Abstract
Onyx (ethylene vinyl copolymer; Medtronic, Minneapolis, MN) is a nonadhesive, nonabsorbable, permanent liquid embolic agent. It is Food and Drug Administration (FDA) approved for preoperative embolization of brain arteriovenous malformations (AVMs). Onyx is composed of an ethylene vinyl alcohol (EVOH) copolymer, dimethyl sulfoxide (DMSO), and micronized tantalum powder. Each substance plays a vital part in the overall effectiveness and delivery at embolization. EVOH is the embolic component and DMSO facilitates delivery through the catheter by acting as a solvent. Micronized tantalum powder allows radiographic visualization. Onyx is available in two concentrations: Onyx 18 (6% EVOH) and Onyx 34 (8% EVOH). Onyx 18 has lower viscosity which allows for greater downstream flow from the delivery microcatheter.
Published Version
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