Abstract
Relevance. The physiotherapy method of dry carbonic acid gas baths (DCAGB) mediated through the effects of carbon dioxide (CO2) is a minimally invasive treatment and prevention method of many human diseases. However, the CO2 effect on the rate of human aging has not been sufficiently studied. Therefore, it is relevant to study the effect of dry carbonic acid gas baths (DCAGB) physiotherapy method on peripheral blood indicators and biological age. Purpose. To assess the effect of carbon dioxide in dry carbonic acid gas baths condition on peripheral blood indicators and biological age in patients of different age groups. Patients and methods. An interventional single center controlled clinical trial was conducted on 140 male patients. Within 1 day before the DCAGB sessions course start (10 sessions 40 minutes each) and 1 day after course completion, patients’ peripheral blood samples were studied, as well as biological and cardiopulmonal age on the patented method was determined. Results. DCAGB course reduced biological age in young and middle-aged patients by 5.5 years (p<0.001), elderly and old patients – by 4.7 years (p<0.001), elderly and old patients had a decrease in cardiopulmonal bio age by 8.6 years (p<0.01). Conclusion. The course of DCAGB sessions slowed the aging rate of the human body from young to old age, which was probably associated with antihypoxic, antitoxic, antioxidant effects of carbon dioxide, as well as possibly with erythropoiesis activation.
Highlights
The problem of organism aging is one of the most pressing issues of the modern science
The LP condition in peripheral blood was assessed by chemiluminescence (СL) of blood plasma induced with hydrogen peroxide on “Lucy3” Anthos Labtec Instruments (Austria) luminometer [22], as well as by the quantity of malondialdehyde (MDA) [23] and dienoic conjugation of higher unsaturated fatty acids (DC) [23, 24]
After the effects of the dry carbonic acid gas baths (DCAGB) course sessions on young and middle-aged patients, in peripheral blood there was a decrease in LP processes intensity with a decrease in lipid peroxidation coefficient (LPC) by 17.7%, (p
Summary
The problem of organism aging is one of the most pressing issues of the modern science. There are many different theories about the causes and mechanisms of living organisms aging, indicating that there is no consensus in understanding this complex process [ 1, 2, 3, 4]. This is the main reason for the lack of universal ways to correct biological age and slow the human aging rate. It has been demonstrated that the discovered medications may well be considered heroprophylactic with the effect of slowing the aging rate [5, 7] This does not give sufficient attention to physiotherapy methods, which are not inferior to medications in their effectiveness. The role of CO2 in the regulation of aging and biological age change is not sufficiently covered in the literature
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