Abstract
An integrated linkage and physical map totalling several hundred microsatellite (MS) and restriction fragment length polymorphisms (RFLP) type markers is being developed for each chromosome of the bovine genome. Templates of evenly spaced markers, that are heterozygous in at least 1 of the parents, can be selected from the integrated map for dissection of family member genomes into smaller marked DNA segments that can be traced following the rules of Mendelian inheritance. This process provides a tool for determining which interval(s) of DNA inherited from the parent are linked to the quantified phenotypic differences among the offspring for any trait of interest. Once linked interval(s) are identified using MS and/or RFLP type markers, the markers can be used to track the linked alleles in marker-assisted-selection (MAS) of animals. Combining MAS technology with advanced reproductive technologies should lead to shortened generation intervals, increased selection intensity and more rapid genetic progress in cattle breeding programs.
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