Abstract
DIISOPROPYL fluorophosphate ("DFP") has been shown to have a marked and prolonged miotic effect in normal men and animals.<sup>1</sup>The miosis may be accompanied with spasm of accommodation and ciliary pain.<sup>2</sup>These effects have been shown to be due entirely to the inactivation of cholinesterase and not to direct action on the iris and ciliary muscle.<sup>3</sup>In this respect "DFP" is similar to physostigmine<sup>4</sup>and neostigmine,<sup>5</sup>but in its reaction with cholinesterase it is at least five and a half times as potent and much more persistent than physostigmine.<sup>6</sup>"DFP" can also overcome the effects of atropine and homatropine on the pupil and ciliary muscle.<sup>3</sup>Finally, "DFP" has been shown to resemble physostigmine in its influence on the intraocular tension of normal human eyes,<sup>1h</sup>differing, however, in that its effect is much more prolonged. Occasional normal human eyes show a rise in
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