Use of Decellularised Porcine Intestinal Submucosa Extracellular Matrix in Airway Reconstruction to Enable Lung-sparing Oncological Surgery

Abstract

Background: Reconstruction of the airways following tracheal or lung-sparing oncological surgery is challenging. A novel approach is the use of bioscaffolds, which allow regeneration of respiratory epithelium and eliminate the need for immunosuppression. Initial experiences with decellularised porcine small intestine submucosa extracellular matrix (CorMatrix) as a scaffold for vascular and cardiac surgery have been encouraging. Its properties are potentially suitable for airway reconstruction.