Abstract
ObjectiveOur aim was to assess renal function using as laboratory measurements serum creatinine and cystatin C concentrations before and after administration of low-osmolarity (nonionic) iodinated contrast medium in patients with cancer undergoing computed tomography (CT).MethodsThis prospective study included 400 oncologic outpatients. Serum creatinine and cystatin C concentrations were measured before and 72 h after contrast administration. Glomerular filtration rates (GFRs) were estimated using serum creatinine–based [Modification of Diet in Renal Disease (MDRD) and Cockroft-Gault and cystatin C based (Larsson) equations. Exploratory data analysis was performed. The nonparametric Wilcoxon test was used to compare pre and post contrast of test results and estimated clearance. The confidence interval used in the analysis was 95%.ResultsCompared with the pre-contrast values, the mean serum creatinine concentration was significantly higher and average GFRs estimated using MDRD and Cockcroft-Gault equations were significantly lower after the administration of contrast (p <0.001). It was also observed a significant increase after contrast in the concentration of Cystatin C (p = 0.015). In addition, a decrease in GFR estimated using the average Larsson (p = 0.021) was observed between time points. However, none of the patients presented clinically significant nephropathy.ConclusionsAssessment using serum creatinine and cystatin C concentrations showed changes in renal function among patients with cancer undergoing contrast-enhanced CT examination in this study. No significant renal damage related to the use of low-osmolarity iodinated contrast medium of the type and dosage employed in this study was observed. This contrast medium is thus safe for use in patients with cancer.
Highlights
An increasing number of patients undergo computed tomography (CT), and the use of iodinated contrast medium is necessary in most cases
Compared with the pre-contrast values, the mean serum creatinine concentration was significantly higher and average Glomerular filtration rates (GFRs) estimated using Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault equations were significantly lower after the administration of contrast (p
The authors have the financial support of the institution where the study was conducted, the AC Camargo Cancer Center, which had no influence on the conduct of the study
Summary
Our aim was to assess renal function using as laboratory measurements serum creatinine and cystatin C concentrations before and after administration of low-osmolarity (nonionic) iodinated contrast medium in patients with cancer undergoing computed tomography (CT). Data Availability Statement: I confirm that all the underlying data to the conclusions of this study are available in the AC Camargo Cancer Center imaging department. This data will be available upon request, because of ethical restrictions. Readers can contact to request the data Mr John Italo F. de Melo, e-mail: italo_me@outlook.com; or by phone 55 11 21895000 / extension 1042/1050.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have