Abstract
The resolution of enantiomers represents an interesting topic of research, especially in the pharmaceutical field. Their separation can be performed using several analytical techniques and among them high performance liquid chromatography (HPLC) and capillary electrophoresis (CE) are the most popular at this moment. Cyclodextrins or their derivatives firstly successful employed in gas chromatography (GC) and liquid chromatography (LC) have been widely studied in CE and resulted to be good resolving agents for a wide number of analytes, mainly of pharmaceutical interest. In this paper the basic principles of enantiomers separation by CE, the parameters affecting the enantioselectivity and resolution are discussed. A comparison between CE and HPLC for optical isomers separation is done.
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