Abstract
Purpose:To compare the use of new cyanoacrylate surgical adhesive associated with macroporous tapes in cutaneous synthesis.Methods:Male Wistar rats with a longitudinal incision of 4cm were used on the back, divided into four groups: GI used octyl-cyanoacrylate (Dermabond®), GII used N-2-butylcyanoacrylate, GIII used octyl-cyanoacrylate and macroporous tape and GIV used N-2-butyl cyanoacrylate and macroporous tape. On the fourteenth day, the rats were submitted to euthanasia, were divided in two parts, and a layer of skin subcutaneous tissue through an area of operative healing was removed. One part was submitted to the study of rupture strength with the use of tensiometer, and in the other part histological examination was performed.Results:No force test was similar between groups I and II, being different from groups III and IV (P <0.001), which were identical to each other (P> 0.05). The units were compared among the studied groups, and they were different with the use of macroporous tapes (P> 0.05).Conclusions:The purpose of macroporous tapes is associated with CA adhesives in cutaneous tissues that provide more resistant scars. The use of a combination of macroporous tapes leads to complete re-epithelialization, without provoking foreign body reaction, has hemostatic properties and does not cause an absorptive reaction.
Highlights
The wound healing process is a sophisticated mechanism dependent on several factors, including the extent and depth of an injury, which will determine a cicatricial response, and the more complicated or timeconsuming wound occlusion will increase the chances of developing a wound of worse quality[1].Tissue damage of any nature immediately triggers a series of events resulting from the activation of cells in the body by chemical and physical stimulation
The purpose of this study was to evaluate a new surgical adhesive composed of N-2-Butylcyanoacrylate produced by the chemistry laboratory of the Federal University of Mato Grosso do Sul Foundation (UFMS) in a cooperation agreement with a private company under protocol number 23104.001269/2010-21 -UFMS where this adhesive could be produced and used locally
When analyzing the rupture strength of the animals submitted to cutaneous synthesis, we found that both groups I and II had significantly weaker scars with 14 days of evolution compared to groups III and IV, but similar to each other, whereas groups III and IV, where a greater rupture strength was performed, were similar to each other
Summary
The wound healing process is a sophisticated mechanism dependent on several factors, including the extent and depth of an injury, which will determine a cicatricial response, and the more complicated or timeconsuming wound occlusion will increase the chances of developing a wound of worse quality[1].Tissue damage of any nature (physical, chemical or biological) immediately triggers a series of events resulting from the activation of cells in the body by chemical and physical stimulation. Fragments of the inert elements of the tissue such as collagen, elastin, fibronectin extravasate from ruptured vessels and by the action of inflammatory mediators culminate with the beginning of the tissue repair process[2]. Research involving wound closure techniques has evolved a lot in recent years, leading to the emergence of several works involving synthetic and absorbable sutures, the use of staplers, tapes, and other methods. The appearance of surgical adhesives fit into the new forms of wound closure and has been studied for approximately four decades[3]. The healing process is dynamic and involves biochemical and physiological events to guarantee tissue repair. It is didactically divided into three phases, taking into account its macroscopic and histological aspects in inflammatory, fibroblast, and remodeling[2]
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